Abstract
The stomach region of hypocatalasemic mice of both sexes was X‐irradiated once with a dose of 20 Gy. Thirteen months after the irradiation, 3 out of 13 (20%) males and 2 out of 9 (15%) females were observed to have developed signet ring cell carcinomas in the glandular stomach. This finding was statistically significant (P < 0.01 in males and P < 0.05 in females) compared to a total absence of similar tumors in the non‐irradiated controls. Local invasion of malignant tumors into muscle and subserosal layers was observed, but no metastatic tumors were found in distant organs.
Keywords: Signet ring cell carcinoma, X‐irradiation, Hypocatalasemic mice
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