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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1991 Mar;82(3):273–279. doi: 10.1111/j.1349-7006.1991.tb01842.x

Lung Cancer Risk among Exsmokers

Tomotaka Sobue 1, Takaichiro Suzuki 1, Isaburo Fujimoto 1, Minoru Matsuda 1, Osamu Doi 1, Akashi Mori 2, Kiyoyuki Furuse 2, Masahiro Fukuoka 3, Tsutomu Yasumitsu 3, Osamu Kuwahara 4, Michio Ichitani 5, Toshihiko Taki 6, Masayoshi Kuwabara 7, Kazuya Nakahara 8, Shozo Endo 9, Kenji Sawamura 9, Masahiko Kurata 9, Shoji Hattori 9
PMCID: PMC5918392  PMID: 1902449

Abstract

Lung cancer risk among exsmokers according to years since cessation of smoking was assessed by means of a case‐control study. The case series consisted of 1,052 lung cancer patients who were newly diagnosed and admitted to eight hospitals in Osaka in 1986–88. Smoking histories were compared with those of 1,111 controls admitted to the same hospitals during the same period without any diagnosis of smoking‐related disease. The odds ratio of lung cancer for exsmokers compared to current smokers was estimated to be 0.90, 0.50, 0.51, 0.59, 0.48 and 0.29, for 1–4, 5–9,10–14,15 19, 20 24 and ± 25 years after cessation of smoking, respectively. Risk reduction appeared to be greater for those who smoked less than the 1200 cigarette index, compared to those who smoked more. In classification according to histologic type, small cell and large cell carcinoma showed a rapid decrease compared to adenocarcinoma, while squamous cell carcinoma showed an intermediate pattern. Quantitative estimates for reduction of lung cancer risk among exsmokers can be used for projecting lung cancer incidence in the future, by assuming future trends of smoking prevalence, as well as for health education among individual smokers.

Keywords: Lung cancer, Exsmoker, Odds ratio

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