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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1991 Jul;82(7):793–799. doi: 10.1111/j.1349-7006.1991.tb02704.x

Effects of 3‐Aminobenzamide on Induction of Multiorgan Carcinogenesis by N‐Nitrosobis(2‐hydroxypropyl)amine in Hamsters

Toshifumi Tsujiuchi 1, Masahiro Tsutsumi 1, Ayumi Denda 1, Toshihiro Amanuma 1, Satoshi Kondoh 1, Kenji Kamino 2, Yoichi Konishi 1,✉
PMCID: PMC5918540  PMID: 1908846

Abstract

The effects of an inhibitor of poly(ADP‐ribose)polymerase, 3‐aminobenzamide (ABA), on N‐nitrosobis(2‐hydroxypropyl)amine (BHP)‐induced pancreas, liver, gallbladder and lung carcinogenesis in Syrian golden hamsters were investigated. Animals were given either BHP alone, by subcutaneous injection at a dose of 500 mg/kg body weight, or in combination with an intraperitoneal injection of ABA 30 min after the BHP at a dose of 300 or 600 mgAg body weight once a week for 5 weeks, and then killed 35 weeks after the commencement of the experiment. ABA exerted inhibitory effects on pancreas and lung carcinogenesis induced by BHP, with mean numbers of lesions (including hyperplasias and carcinomas) being significantly decreased compared with the BHP‐alone group values, while no significant effect was observed on liver or gallbladder carcinogenesis. These results suggest that the effects of ABA on carcinogenesis depend on the target organ as well as the chemical carcinogen examined.

Keywords: Multiorgan carcinogenesis, Poly(ADP‐ribose)polymerase, 3‐Aminobenzamide, N‐Nitrosobis(2‐hydroxypropyl)amine, Hamster

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