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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1991 Aug;82(8):934–941. doi: 10.1111/j.1349-7006.1991.tb01924.x

Abnormal Expression of Blood Group–related Antigens in Uterine Endometrial Cancers

Katsumi Tsukazaki 1, Motoko Sakayori 1, Hiroharu Arai 2, Kanji Yamaoka 3, Soju Kurihara 3, Shiro Nozawa ✉
PMCID: PMC5918579  PMID: 1910029

Abstract

The expression of A, B, and H group antigens, Lewis group antigens (Lewisa, Lewisb, Lewisx, and Lewisy), and Lc4 and nLc4 antigens, the precursor antigens of both groups, was examined immunohistochemically with monoclonal antibodies in 9 normal endometria, 6 endometrial hyperplasias, and 31 endometrial cancers. 1) A, B and/or H antigens were detected in endometrial cancers at an incidence of 51.6%, while no distinct localization of these antigens was observed in normal endometria. H antigen, the precursor of A and B antigens, was particularly frequently detected in endometerial cancers. 2) An increased rate of expression of Lewis group antigens, particularly Lewisb antigen, was observed in endometrial cancers compared with its expression in normal endometria. 3) Lc4 and nLc4 antigens were detected in endometrial cancers at rates of 41.9% and 38.7%, respectively, these expressions being increased compared with those in normal endometria. 4) These results suggest that a highly abnormal expression of blood group–related antigens in endometrial cancers occurs not only at the level of A, B, and H antigens and Lewis group antigens, but also at the level of their precursor Lc4 and nLc4 antigens. 5) Lewisa, Lewisb, and Lc4 antigens, built on the type–1 chain, are more specific to endometrial cancers than their respective positional isomers, Lewisx, Lewisy, and nLc4 antigens, built on the type–2 chain.

Keywords: Blood group, related antigens, Lc4, nLc4, Monoclonal antibody, Imraunohistochemistry, Endometrial cancer

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