Abstract
A female F344 rat was injected with 2.4 × 106 MT‐2 cells intravenously at 3 and 4 weeks old, and was mated with a non‐infected male rat at the 17th week after injection, when the dam rat contained HTLV‐1 provirus in the peripheral blood mononuclear cells as determined by polymerase chain reaction. HTLV‐1 provirus was detected in at least 2 out of 9 offspring. This system should be useful for studies on the routes and prevention of vertical transmission and on elimination of once‐transmitted HTLV‐1.
Keywords: Vertical transmission, HTLV‐1, HTLV‐1 carrier, PCR, Rat model
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