Abstract
CD7 antigen was found to be expressed on malignant mesothelioma arising from the right pleura in a 15‐year‐old girl not only by immunostaining using monoclonal antibodies, but also by Northern blot analysis. The level of expression in this tumor was comparable to those in T‐cell lines, Jurkat and CCRF‐CEM. Cytogenetic analysis of the tumor showed hypodiploidy (n = 43). CD7 has been regarded as one of the hematopoietic cell markers selectively expressed on the majority of T cells and multipotential stem cells. To our knowledge, this is the first report of a non‐hematopoietic tumor expressing CD7.
Keywords: Key words, CD7, CD56, Malignant pleural mesothelioma, Soft tissue sarcoma
Full Text
The Full Text of this article is available as a PDF (353.8 KB).
REFERENCES
- 1. ) Haynes , B. F. , Eisenbarth , G. S. and Fauci , A. S.Human lymphocyte antigens: production of a monoclonal antibody that defines functional thymus‐derived lymphocyte subsets . Proc. Natl. Acad. Sci. USA , 76 , 5829 – 5833 ( 1979. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2. ) Southerland , D. R. , Rudd , C. E. and Greaves , M. F.Isolation and characterization of a human T lymphocyte‐associated glycoprotein (gp40) . J. Immunol , 133 , 327 – 333 ( 1984. ). [PubMed] [Google Scholar]
- 3. ) Schanberg , L. E. , Fleenor , D. E. , Kurtzberg , J. and Haynes , B. F.Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy‐1 gene . Proc. Natl. Acad. Sci. USA , 80 , 603 – 607 ( 1991. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4. ) Haynes , B. F. , Denning , S. M. , Singe , K. H. and Kurtzberg , J.Ontogeny of T‐cell precursors: a model for the initial stages of human T‐cell development . Immunol. Today , 10 , 87 – 91 ( 1989. ). [DOI] [PubMed] [Google Scholar]
- 5. ) Mossalayi , M. D. , Dalloul , A. H. , Bertho , J. and Lecron , J.In vitro differentiation and proliferation of purified human thymic and bone marrow CD7+ CD2‐ T‐cell precursors . Exp. Hematol. , 18 , 326 – 331 ( 1990. ). [PubMed] [Google Scholar]
- 6. ) Lobach , D. F. , Hensley , L. L. , Ho , W. and Haynes , B. F.Human T cell antigen expression during the early stages of fetal thymic maturation . J. Immunol , 135 , 1752 – 1759 ( 1985. ). [PubMed] [Google Scholar]
- 7. ) Haynes , B. F. , Martin , M. E. , Kay , H. H. and Kurtzberg , J.Early events in human T cell ontogeny . J. Exp. Med. , 168 , 1061 – 1080 ( 1988. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8. ) “ Histological Typing of Lung Tumors ,” 2nd Ed. ( 1981. ). World Health Organization; , Geneva . [Google Scholar]
- 9. ) Manning , L. S. , Whitaker , D. , Murch , A. R. , Garlepp , M. J. , Davis , M. R. , Musk , A. W. and Robinson , B. W. S.Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions . Int. J. Cancer , 47 , 285 – 290 ( 1991. ). [DOI] [PubMed] [Google Scholar]
- 10. ) Fletcher , J. A. , Kozakewich , H. P. , Hoffer , F. A. , Lage , J. M. , Weidner , N. , Tepper , R. , Pinkus , G. S. , Morton , C. C. and Corson , J. M.Diagnostic relevance of clonal cytogenetic aberrations in malignant soft‐tissue tumors . N. Engl. J. Med. , 324 , 436 – 442 ( 1991. ). [DOI] [PubMed] [Google Scholar]
- 11. ) Aruffo , A. and Seed , B.Molecular cloning of two CD7 (T‐cell leukemia antigen) cDNAs by a COS cell expression system . EMBO J. , 6 , 3313 – 3316 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12. ) Ware , R. E. , Scearce , R. M. , Dietz , M. A. , Starmer , C. F. , Palker , T. J. and Haynes , B. F.Characterization of the surface topography and putative tertiary structure of the human CD7 molecule . J. Immunol , 143 , 3632 – 3640 ( 1989. ). [PubMed] [Google Scholar]
- 13. ) Sandrin , M. S. , Vaughan , H. A. , Lovering , K. E. , Curnow , K. , Deacon , N. J. and McKenzie , I. F. C.Characterization of the gene coding for the human lymphocyte surface antigen HuLy‐m2 (CD7) . In “ Leukocyte Typing HI ,” ed. McMichael A. J. , p. 216 ( 1987. ). Oxford University Press; , Oxford . [Google Scholar]
- 14. ) Ebener , U. , Wehner , S. , Cinatl , J. , Gussetis , E. S. and Kornhuber , B.Expression of markers shared between human haematopoietic cells and neuroblastoma cells . Anticancer Res. , 10 , 887 – 890 ( 1990. ). [PubMed] [Google Scholar]
- 15. ) Baker , E. , Sandrin , M. S. , Garson , O. M. , Southerland , G. R. , McKenzie , I. F. C. and Webber , L. M.Localization of the cell surface antigen CD7 by chromosomal in situ hybridization . Immunogenetics , 31 , 412 – 413 ( 1990. ). [DOI] [PubMed] [Google Scholar]
- 16. ) Osada , H , Emi , N. , Ueda , R. , Seto , M. , Koike , K. , Suchi , T. , Kojima , S. , Obata , Y. and Takahashi , T.Genuine CD7 expression in acute leukemia and lymphoblastic lymphoma . Leuk. Res. , 14 , 869 – 877 ( 1990. ). [DOI] [PubMed] [Google Scholar]