Abstract
Photodynamic therapy utilizing Photofrin has proven to be an effective modality that can be used in the treatment of a wide variety of solid tumors and luminal cancers. An argon pumped dye laser or excimer dye laser was used to deliver 630 nm light via quartz fibers passed through the biopsy channel subsequent to i.v. injection of photosensitizer. In this study, 64 patients with superficial cancers were treated in this manner but only 58 patients, including 21 with roentgenographically occult lung cancer, 8 with stage I lung cancer, 5 with esophageal cancer, 12 with gastric cancer, 8 with cervical cancer and 4 with bladder cancer were evaluable. Complete remission was obtained in 48 out of 58 cases (82.8%). There was no serious complication except skin photosensitivity, which was seen in 13 patients. We conclude that photodynamic therapy is efficacious in the treatment of superficial cancers where complete remission may be achieved.
Keywords: Photodynamic therapy, Photofrin, Argon dye laser, Excimer dye laser
Full Text
The Full Text of this article is available as a PDF (300.6 KB).
REFERENCES
- 1. ) Raab , O.Uber die Wirkung fluoreszierender Stoffe auf Infusoria . Z. Biol. , 39 , 524 – 546 ( 1990. ). [Google Scholar]
- 2. ) Lipson , R. I. , Baldes , E. S. and Olsen , A. M.The use of a derivative of hematoporphyrin in tumor detection . J. Natl. Cancer Inst. , 26 , 1 – 8 ( 1961. ). [PubMed] [Google Scholar]
- 3. ) Dougherty , T. J. , Laurence , G. , Kaufman , J. H. , Boyle , D. G. , Weishaupt , K. R. and Goldfarb , A.Photoradiation in the treatment of recurrent breast carcinoma . J. Natl. Cancer Inst. , 62 , 231 – 237 ( 1979. ). [PubMed] [Google Scholar]
- 4. ) Dougherty , T. J.Photosensitization of malignant tumor . Semin. Surg. Oncol. , 2 , 24 – 37 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 5. ) Weishaupt , K. R. , Comer , C. J. and Dougherty , T. J.Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor . Cancer Res. , 36 , 2326 – 2329 ( 1976. ). [PubMed] [Google Scholar]
- 6. ) Berns , M. W. , Dahlman , A. and Johnson , F. M.In vitro cellular effects of hematoporphyrin derivative . Cancer Res. , 42 , 2325 – 2329 ( 1982. ). [PubMed] [Google Scholar]
- 7. ) Kato , H. , Aizawa , K. , Shinohara , H. , Konaka , C. and Hayata , Y.Cytomorphological changes caused by hematoporphyrin derivative and photodynamic therapy . Laser Life Sci. , 1 , 13 – 27 ( 1986. ). [Google Scholar]
- 8. ) Henderson , B. W. , Waldow , S. M. and Mang , T. S.Tumor destruction and kinetics of tumor cell death in two experimental mouse tumors following photodynamic therapy . Cancer Res. , 45 , 572 – 576 ( 1985. ). [PubMed] [Google Scholar]
- 9. ) Kato , H. , Kawate , N. , Kinoshita , K. , Yamamoto , H. , Furukawa , K. and Hayata , Y.Photodynamic therapy of early‐stage lung cancer . In “ Photosensitizing Compounds: Their Chemistry, Biology and Clinical Use ,” ed. Bock G. and Harnett S. , pp. 531 – 535 ( 1990. ). John Wiley and Sons; , Chichester . [Google Scholar]
- 10. ) Tenjin , Y. , Sakunaga , H. , Sakamoto , M. , Muroya , T. , Sugita , M. , Sugishita , T. , Hirano , T. , Suzuki , K. and Miyaki , M.Excimer dye laser therapy for early stage cervical cancer . Obstet. Gynecol. Ther. , 61 , 987 – 992 ( 1990. ) ( in Japanese ). [Google Scholar]
- 11. ) Okunaka , T. , Kato , H. , Konaka , C. , Yamamoto , H. , Bonaminio , A. and Eckhauser , M. L.Photodynamic therapy of esophageal carcinoma . Surg. Endosc. , 4 , 150 – 153 ( 1990. ). [DOI] [PubMed] [Google Scholar]
- 12. ) MaCaughan , J. S. , Nims , T. A. , Guy , J. T. , Hicks , W. J. , Williams , T. E. and Laufman , L. R.Photodynamic therapy for esophageal tumors . Arch. Surg. , 124 , 74 – 80 ( 1989. ). [DOI] [PubMed] [Google Scholar]
- 13. ) Mimura , S. , Ichii , M. , Imanishi , K. , Tatsuta , M. , Otani , T. and Okuda , S.Evaluation of photodynamic therapy for gastric cancer . Dig. Endosc. , 2 , 265 – 274 ( 1990. ). [Google Scholar]
- 14. ) Naito , K. , Hisazumi , H. , Uchibayashi , T. , Amano , T. , Hirata , A. , Komatsu , K. , Ishida , T. and Miyoshi , N.Integral laser photodynamic treatment of refractory multifocal bladder tumors . J. Urol. , 146 , 1541 – 1545 ( 1991. ). [DOI] [PubMed] [Google Scholar]
- 15. ) Kato , H. , Kito , T. , Furuse , K. , Sakai , E. , Ito , K. , Mimura , S. , Okushima , N. , Maiyo , K. and Suzuki , S.Photodynamic therapy, for early treatment of cancer . Jpn. J. Cancer Chemother. , 17 , 1833 – 1838 ( 1990. ). [PubMed] [Google Scholar]
- 16. ) MaCaughan , J. S. , Guy , J. T. , Hawley , P. , William , H. , Williams , I. and Laufman , L. R.Hematoporphyrin‐derivative and photodynamic therapy of malignant tumors . Laser Surg. Med. , 3 , 199 – 209 ( 1983. ). [DOI] [PubMed] [Google Scholar]
- 17. ) Wooten , R. S. , Smith , K. S. and Ahlquest , D. A.Prospective study of cutaneous phototoxicity after systemic hematoporphyrin derivative . Laser Surg. Med. , 8 , 294 – 300 ( 1988. ). [DOI] [PubMed] [Google Scholar]