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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1994 Jul;85(7):718–722. doi: 10.1111/j.1349-7006.1994.tb02420.x

Establishment of a Human Small Cell Lung Cancer Cell Line Producing a Large Amount of Anti‐diuretic Hormone

Takeo Terasaki 1, Yoshihiro Matsuno 1, Yukio Shimosato 3, Ken Yamaguchi 2, Hiroshi Ichinose 4, Toshiharu Nagatsu 4, Kanefusa Kato 5
PMCID: PMC5919549  PMID: 8071114

Abstract

A new cancer cell line (Lu‐165) producing a large amount of anti‐diuretic hormone (ADH, 2.8 μg/g protein) was established from a 50‐year‐old small cell lung cancer patient presenting with a syndrome of inappropriate anti‐diuretic hormone secretion. These cells grew well in serum‐supplemented medium and during more than 100 passages they continued producing a large amount of this hormone. This cell line will be a useful tool for studies of the biochemistry and pathology of ADH‐producing cancer.

Keywords: Anti‐diuretic hormone, Small cell lung cancer, Cell line

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