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. 1994 Aug;85(8):767–770. doi: 10.1111/j.1349-7006.1994.tb02945.x

Subtype Analysis of HTLV‐1 in Patients with HTLV‐1 Uveitis

Ayako Ono 1,2, Tomoyuki Miura 3, Shinji Araki 4, Kazunari Yamaguchi 5, Kiyoshi Takatsuki 5, Sigeo Mori 1, Masanori Hayami 3, Manabu Mochizuki 2, Toshiki Watanabe 1,✉
PMCID: PMC5919557  PMID: 7928620

Abstract

The hypothesis that HTLV‐1 uveitis, a recently identified disease entity associated with human T‐cell leukemia virus type I (HTLV‐1), is caused by a specific subtype of the virus was tested. The nucleotide sequences of the long terminal repeat of HTLV‐1 from five patients with HTLV‐1 uveitis (HU) and four with adult T‐cell leukemia were phylogenetically analyzed. Our results showed that both subtypes which had been identified in Japan were associated with HU, indicating that there was no difference in pathogenicity between these phylogenetic subtypes. One of the subtypes was more frequently isolated in Okinawa than in Kyushu, suggesting a bias in the prevalence of each subtype among the inhabitants of these two areas of Japan.

Keywords: HTLV‐1 uveitis, ATL, LTR sequence, phylogenic subtype

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