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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1995 Jul;86(7):649–654. doi: 10.1111/j.1349-7006.1995.tb02448.x

A Maternal Risk Factor for Mother‐to‐Child HTLV‐I Transmission: Viral Antigen‐producing Capacities in Culture of Peripheral Blood and Breast Milk Cells

Mitsuhiro Yoshinaga 1,✉, Shinji Yashiki 2, Toshitaka Oki 1, Toshinobu Fujiyoshi 2, Yukihiro Nagata 1, Shunro Sonoda 2
PMCID: PMC5920895  PMID: 7559082

Abstract

We examined the relationship between productivity of HTLV‐I antigen‐positive cells in cultured peripheral blood mononuclear cells (PBMC) and breast milk mononuclear cells (BMMC) and the incidence of mother‐to‐child transmission of HTLV‐I. Among 61 cases of HTLV‐I carrier mothers, 17 cases were revealed to produce large numbers of HTLV‐I antigen‐positive cells (high HTLV‐I antigen‐producing mothers) whose positive rate was 9.6% in PBMC and 10.2% in BMMC, while the remaining 44 cases produced small numbers of HTLV‐I antigen‐positive cells (low HTLV‐I antigen‐producing mothers) whose positive rate was 0.3% In PBMC and 0.5% in BMMC. The HTLV‐I transmission rate among children born to the high HTLV‐I antigen‐producing mothers was 37.5% (6/16 children from 11 mothers), while that of the low HTLV‐I antigen‐producing mothers was 3.2% (1/31 children from 20 mothers). The transmission rate of HTLV‐I was significantly different between high and low HTLV‐I antigen‐producing mothers (P<0.05). However, there was no positive relationship between anti‐HTLV‐I antibody titers and productivity of HTLV‐I antigen‐positive cells (P=0.11). These results suggested that mother‐to‐child transmission of HTLV‐I might be influenced by a maternally determined factor to produce HTLV‐I antigen‐positive cells in PBMC and BMMC of HTLV‐I carrier mothers.

Keywords: HTLV‐I, Mother‐to‐child transmission, HTLV‐I antigen‐positive cells, Peripheral blood and breast milk

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REFERENCES

  • 1. ) Hino , S. , Yamaguchi , K. , Katamine , S. , Sugiyama , H. , Amagasaki , T. , Kinoshita , K. , Yoshida , Y. , Doi , H. , Tsuji , Y. and Miyamoto , T.Mother‐to‐child transmission of human T‐cell leukemia virus type‐1 . Jpn. J. Cancer Res. , 76 , 474 – 480 ( 1985. ). [PubMed] [Google Scholar]
  • 2. ) Tajima , K. , Tominaga , S. , Suchi , T. , Kawagoe , T. , Komada , H. , Hinuma , Y. , Oda , T. and Fujita , K.Epidemiological analysis of the distribution of antibody to adult T‐cell leukemia‐virus‐associated antigen: possible horizontal transmission of adult T‐cell leukemia virus . Gann , 73 , 893 – 901 ( 1982. ). [PubMed] [Google Scholar]
  • 3. ) Kajiyama , W. , Kashiwagi , S. , Ikematsu , H. , Hayashi , J. , Nomura , H. and Okochi , K.Intrafamilial transmission of adult T‐cell leukemia virus . J. Infect. Dis. , 154 , 851 – 857 ( 1986. ). [DOI] [PubMed] [Google Scholar]
  • 4. ) Kinoshita , K. , Yamanouchi , K. , Ikeda , S. , Momita , S. , Amagasaki , T. , Soda , H. , Ichimura , M. , Moriuchi , R. , Katamine , S. , Miyamoto , T. and Hino , S.Oral infection of a common marmoset with human T‐cell leukemia virus type‐I (HTLV‐I) by inoculating fresh human milk of HTLV‐I carrier mothers . Jpn. J. Cancer Res. , 76 , 1147 – 1153 ( 1985. ). [PubMed] [Google Scholar]
  • 5. ) Iwahara , Y. , Kataoka , R. , Sawada , T. , Ohtsuki , Y. , Nakachi , H. , Maehama , T. , Okayama , T. and Miyoshi , I.Transmission of HTLV‐I to rabbits via semen and breast milk from seropositive healthy persons . Int. J. Cancer , 45 , 980 – 983 ( 1990. ). [DOI] [PubMed] [Google Scholar]
  • 6. ) Hino , S. , Sugiyama , H. , Doi , H. , Ishimaru , T. , Yamabe , T. , Tsuji , Y. and Miyamoto , T.Breaking the cycle of HTLV‐I transmission via carrier mothers' milk . Lancet , ii , 158 – 159 ( 1987. ). [DOI] [PubMed] [Google Scholar]
  • 7. ) Ando , Y. , Nakano , S. , Saito , K. , Shimamoto , I. , Ichijo , M. , Toyama , T. and Hinuma , Y.Transmission of adult T‐cell leukemia retrovirus (HTLV‐I) from mother to child: comparison of bottle‐ with breast‐fed babies . Jpn. J. Cancer Res. , 78 , 322 – 324 ( 1987. ). [PubMed] [Google Scholar]
  • 8. ) Oki , T. , Yoshinaga , M. , Otsuka , H. , Miyata , K. , Sonoda , S. and Nagata , Y.A sero‐epidemiological study on mother‐to‐child transmission of HTLV‐I in southern Kyusyu, in Japan . Asia-Oceania J. Obstet. Gynaecol. , 18 , 371 – 377 ( 1992. ). [DOI] [PubMed] [Google Scholar]
  • 9. ) Sugiyama , H. , Doi , H. , Yamaguchi , K. , Tsuji , Y. , Miyamoto , T. and Hino , S.Significance of postnatal mother‐to‐child transmission of human T‐lymphotropic virus type‐I on the development of adult T‐cell leukemia/lymphoma . J. Med. Virol. , 20 , 253 – 260 ( 1986. ). [DOI] [PubMed] [Google Scholar]
  • 10. ) Takahashi , K. , Takezaki , T. , Oki , T. , Kawakami , K. , Yashiki , S. , Fujiyoshi , T. , Usuku , K. , Mueller , N. , The mother‐to‐child transmission study group , Osame , M. , Miyata , K. , Nagata , Y. and Sonoda , S.Inhibitory effect of maternal antibody on mother‐to‐child transmission of human T‐lymphotropic virus type I . Int. J. Cancer , 49 , 673 – 677 ( 1991. ). [DOI] [PubMed] [Google Scholar]
  • 11. ) Yamanouchi , K. , Kinoshita , K. , Moriuchi , R. , Katamine , S. , Amagasaki , T. , Ikeda , S. , Ichimura , M. , Miyamoto , T. and Hino , S.Oral transmission of human T‐cell leukemia virus type‐I into a common marmoset (Callithrix jacchus) as an experimental model for milk‐borne transmission . Jpn. J. Cancer Res. , 76 , 481 – 487 ( 1985. ). [PubMed] [Google Scholar]
  • 12. ) Akagi , T. , Takeda , I. , Oka , T. , Ohtsuki , Y. , Yano , S. and Miyoshi , I.Experimental infection of rabbits with human T‐cell leukemia virus type I . Jpn. J. Cancer Res. , 76 , 86 – 94 ( 1985. ). [PubMed] [Google Scholar]
  • 13. ) Nakano , S.Search for possible routes of vertical infection of adult T‐cell leukemia virus (ATLA): evidence of viral transmission from mother to child . Acta Obstet. Gynaecol. Jpn. , 38 , 2274 – 2282 ( 1986. ). [PubMed] [Google Scholar]
  • 14. ) Saito , S. , Furuki , Y. , Ando , Y. , Tanigawa , T. , Kakimoto , K. , Moriyama , I. and Ichijo , M.Identification of HTLV‐I sequence in cord blood mononuclear cells of neonates born to HTLV‐I antigen/antibody‐positive mothers by polymerase chain reaction . Jpn. J. Cancer Res. , 81 , 890 – 895 ( 1990. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15. ) Kawase , K. , Katamine , S. , Moriuchi , R. , Miyamoto , T. , Kubota , K. , Igarashi , H. , Doi , H. , Tsuji , Y. , Yamabe , T. and Hino , S.Maternal transmission of HTLV‐1 other than through breast milk: discrepancy between the polymerase chain reaction positivity of cord blood samples for HTLV‐1 and the subsequent seropositivity of individuals . Jpn. J. Cancer Res. , 83 , 968 – 977 ( 1992. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16. ) Kinoshita , K. , Hino , S. , Amagasaki , T. , Ikeda , S. , Yamada , Y. , Suzuyama , J. , Momita , S. , Toriya , K. , Kamihira , S. and Ichimaru , M.Demonstration of adult T‐cell leukemia virus antigen in milk from three seropositive mothers . Gann , 75 , 103 – 105 ( 1984. ). [PubMed] [Google Scholar]
  • 17. ) Hinuma , Y. , Nagata , K. , Hanaoka , M. , Nakai , M. , Matsumoto , T. , Kinoshita , K. , Shirakawa , S. and Miyoshi , I.Adult T‐cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera . Proc. Natl. Acad. Sci. USA , 78 , 6476 – 6480 ( 1981. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18. ) Katahira , Y. , Yashiki , S. , Fujiyoshi , T. , Nomura , K. , Tara , M. , Mori , M. , Setoyama , M. , Kanzaki , T. , Shida , H. and Sonoda , S.In vitro induction of cytotoxic T lymphocytes against HTLV‐I‐infected T‐cells from adult T‐cell leukemia patients, asymptomatic HTLV‐I carriers and seronegative healthy donors . Jpn. J. Cancer Res. , 86 , 21 – 27 ( 1995. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19. ) Tanaka , Y. , Koyanagi , Y. , Chosa , T. , Yamamoto , N. and Hinuma , Y.Monoclonal antibody reactive with both p28 and p19 of adult T‐cell leukemia virus‐specific polypeptides . Gann , 74 , 327 – 330 ( 1983. ). [PubMed] [Google Scholar]
  • 20. ) Sugamura , K. , Fujii , M. , Ueda , S. and Hinuma , Y.Identification of a glycoprotein, gp21, of adult T cell leukemia virus by monoclonal antibody . J. Immunol. , 132 , 3180 – 3184 ( 1984. ). [PubMed] [Google Scholar]
  • 21. ) Yoshida , M. , Osame , M. , Kawai , H. , Toita , M. , Kuwasaki , N. , Nishida , Y. , Hiraki , Y. , Takahashi , K. , Nomura , K. , Sonoda , S. , Eiraku , N. , Ijichi , S. and Usuku , K.Increased replication of HTLV‐I in HTLV‐I‐associated myelopathy . Ann. Neurol. , 26 , 331 – 335 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 22. ) Sonoda , S. , Yashiki , S. , Fujiyoshi , T. , Arima , N. , Tanaka , H. , Eiraku , N. , Izumo , S. and Osame , M.Immunogenetic factors involved in the pathogenesis of adult T‐cell leukemia and HTLV‐I‐associated myelopathy . Gann Monogr. Cancer Res. , 39 , 81 – 93 ( 1992. ). [Google Scholar]
  • 23. ) Jacobson , S. , Gupta , A. , Mattson , D. , Mingioli , E. and McFarlin , D. E.Immunological studies in tropical spastic paraparesis . Ann. Neurol. , 27 , 149 – 156 ( 1990. ). [DOI] [PubMed] [Google Scholar]
  • 24. ) Usuku , K. , Sonoda , S. , Osame , M. , Yashiki , S. , Takahashi , K. , Matsumoto , M. , Sawada , T. , Tsuji , K. , Tara , M. and Igata , A.HLA haplotype‐linked high immune responsiveness against HTLV‐1‐associated myelopathy: comparison with adult T‐cell leukemia/lymphoma . Ann. Neurol. , 23 ( Suppl. ), s143 – 150 ( 1988. ). [DOI] [PubMed] [Google Scholar]
  • 25. ) Jacobson , S. , Shida , H. , McFarlin , D. E. , Fauci , A. S. and Koenig , S.Circulating CD8+ cytotoxic T lymphocytes specific for HTLV‐I pX in patients with HTLV‐I associated neurological disease . Nature , 348 , 245 – 248 ( 1990. ). [DOI] [PubMed] [Google Scholar]
  • 26. ) Kannagi , M. , Matsushita , S. and Harada , S.Expression of the target antigen for cytotoxic T lymphocytes on adult T‐cell‐leukemia cells . Int. J. Cancer , 54 , 582 – 588 ( 1993. ). [DOI] [PubMed] [Google Scholar]
  • 27. ) Ueda , K. , Kusuhara , K. , Tokugawa , K. , Miyazaki , C. , Yoshida , C. , Tokumura , K. , Sonoda , S. and Takahashi , K.Cohort effect on HTLV‐I seroprevalence in southern Japan . Lancet , ii , 979 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 28. ) Oguma , S.Simulation of dynamic changes of human T‐cell leukemia virus type I carriage rates . Jpn. J. Cancer Res. , 81 , 15 – 21 ( 1990. ). [DOI] [PMC free article] [PubMed] [Google Scholar]

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