Abstract
The murine spontaneous B lymphoma is etiologically related to the expression of endogenous ecotropic marine leukemia virus (ETV). Although both SL/Kh and SL/Ni mouse strains show a high level of expression of ETV from early in life, the former is a pre‐B lymphoma‐prone strain and the latter is rather lymphoma‐resistant. In order to identify the host background difference related to the lymphomagenesis, we performed a genetic cross study between these two strains. In the reciprocal F1 generation, the length of the lymphoma latent period was slightly but significantly longer in (SL/Ni XSL/Kh)F1 than in (SL/Kh × SL/Ni)F1 (P<0.05). The incidence of overall lymphomas and that of acute pre‐B lymphomas was lower in (SL/Ni × SL/Kh)F1 than in (SL/Kh × SL/Ni)F1, although the difference was not statistically significant. These observations indicate that an epigenetic maternal resistance mechanism of SL/Ni mice plays a role in the lymphoma resistance. Furthermore, in the backcross combinations without maternal influence of SL/Ni, we observed a genetic mechanism of lymphoma resistance: an SL/Ni‐derived recessive lymphoma‐resistance gene mapped in the proximal segment of Chr. 4. We named this gene nir‐1 (SL/Ni‐lymphoma resistance‐1). Thus, we have demonstrated epigenetic and genetic mechanisms of lymphoma resistance of the SL/Ni mouse with the high expression of endogenous ETV.
Keywords: Mouse lymphoma, Genetic resistance, Maternal effect, Microsatellite analysis, SL/Ni mouse
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