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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1997 Apr;88(4):401–406. doi: 10.1111/j.1349-7006.1997.tb00396.x

Expression of Interstitial Collagenase (Matrix Metalloproteinase‐1) in Gastric Cancers

Yoshihiko Sakurai 1, Yoshihide Otani 1,✉, Kaori Kameyama 2, Yasuhiro Hosoda 2, Isao Okazaki 3, Tetsuro Kubota 1, Koichiro Kumai 1, Masaki Kitajima 1
PMCID: PMC5921419  PMID: 9197533

Abstract

The expression of matrix metalloproteinase‐1 (MMP‐1) gene and the presence of MMP‐1 protein in gastric cancer were examined by in situ hybridization and immunohistochemistry. Expression of the interstitial Collagenase (MMP‐1) gene was detected within the stroma of the neoplastic glands, and infiltration of eosinopilic was observed to be associated with regions of MMP‐1 gene expression. The degree of eosinophils infiltration correlated with the level of MMP‐1 mRNA expression. Immunostaining showed localization of MMP‐1 protein in the stromal cells, and additionally in the neoplastic glands. These findings indicate that the stromal cells may play an important role in the expression of MMP‐1, and suggest a pathophysiological role for MMP‐1 in the invasion and metastasis of gastric cancer.

Keywords: Matrix metalloproteinase‐1, Collagenase, Eosinophil, Gastric cancer, Stromal cell

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