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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1997 Apr;88(4):427–434. doi: 10.1111/j.1349-7006.1997.tb00400.x

Radioimmunodetection with 111In–labeled Monoclonal Antibody Nd2 in Patients with Pancreatic Cancer

Yong‐Suk Chung 1,✉, Tetsuji Sawada 1, Yasuyuki Kondo 1, Koji Hirayama 1, Akimasa Inui 1, Yoshito Yamashita 1, Bunzo Nakata 1, Terue Okamura 2, Hironobu Ochi 2, Jenny J L Ho 3, Young S Kim 3, Michio Sowa 1
PMCID: PMC5921428  PMID: 9197537

Abstract

This report summarizes results from an initial clinical evaluation of radioimnumodetection (RAID) in patients with pancreatic cancer using murine monoclonal antibody Nd2, directed against mucins from pancreatic cancer.Nd2 (2 mg) was labeled with 111ln (2 mCi) and injected into 19 patients suspected of having pancreatic cancer. Planar scintigrams were taken 3 days post–infusion. As for final diagnoses after surgery, 14 cases were pancreatic cancer, and one case each was chronic pancreatitis, neurilem–moma, islet cell carcinoma, cholangioma, and apparent absence of suspected recurrent lesion of pancreatic cancer. Of 14– patients with pancreatic cancer, RAID was positive in 10 cases (71.4%). Cases other than pancreatic cancer were all negative, so the specificity was 100%. These results demonstrate that RAID using 111In–Nd2 can be useful in differentiating exocrine pancreatic cancer from benign conditions and other types of carcinomas in the pancreatoduodenal regions.

Keywords: Radioimmunodetection, Pancreatic cancer, Nd2, Indium

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