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. 1998 Feb;89(2):105–109. doi: 10.1111/j.1349-7006.1998.tb00536.x

Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide

Kiyoshi Takegawa 1, Kunitoshi Mitsumori 1,✉, Hiroshi Onodera 1, Kazuo Yasuhara 1, Keisuke Kitaura 1, Takeo Shimo 1, Michihito Takahashi 1
PMCID: PMC5921766  PMID: 9548435

Abstract

In a 2‐year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high‐dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non‐genotoxic, proliferation‐dependent mechanism.

Keywords: Squamous cell carcinoma, Salivary gland, Potassium iodide, Rat

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