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. 1998 May;89(5):578–582. doi: 10.1111/j.1349-7006.1998.tb03300.x

Increased Proliferation of Myoblasts after Cyclic Plasma Perfusion of Tumor‐bearing Rabbits

Shin‐ichi Nakata 1,†, Osamu Ishiko 1,✉, Ken‐ichi Honda 1, Kouzo Hirai 1, Masaaki Deguchi 1, Sachio Ogita 1
PMCID: PMC5921846  PMID: 9685863

Abstract

Rabbits implanted with VX2 carcinoma and treated by cyclic plasma perfusion showed lower weight loss and longer survival than untreated rabbits. The urinary 3‐methylhistidine/creatinine ratio was less elevated in the treated rabbits than in the untreated rabbits. Myoblasts from untreated rabbits with VX2 carcinoma showed lower proliferation than those from normal rabbits, while those from rabbits treated by cyclic plasma perfusion showed intermediate proliferation. Furthermore, the DNA synthesis rate of myoblasts from treated rabbits was much better maintained than in the case of untreated rabbits.

Keywords: Key words, Anemia‐inducing substance, Plasma perfusion, 3‐Methylhistidine, Myoblast, Cancer cachexia

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