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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1998 Jun;89(6):597–603. doi: 10.1111/j.1349-7006.1998.tb03260.x

Association of Helicobacter pylori Infection with Gastric Adenocarcinoma

Byung Mu Lee 1,✉, Ja‐June Jang 2, Joung‐Soon Kim 3, Young Chan You 4, Sun Ah Chun 1, Hyung Sik Kim 1, Hyung Mee Han 5, Mi Young Ahn 1, Soo Hyun Byun 1
PMCID: PMC5921873  PMID: 9703356

Abstract

Gastric adenocarcinoma is the most prevalent cancer in South Korea, and Helicobacter pylori (H. pylori) infection is also common. This study was performed to examine the association between H. pylori infection and gastric cancer, taking into account various other factors. To investigate the association between gastric adenocarcinoma and H. pylori infection, determined by urease‐positive reaction in the CLO test, a total of 175 paired specimens (175 tumor and 175 tissues adjacent to tumor) of stomach cancer patients and a total of 113 control specimens were obtained. The positive H. pylori infection rates were 78.9% (138/175) among the patients in specimens of tumor or tissues adjacent to the tumor and 41.6% (47/113) among controls in the CLO test. A positive correlation between H. pylori infection and gastric cancer was observed (age‐adjusted odds ratio, 7.0; MH χ2=34.5 with P<0.0005). These data suggest that stomach cancer patients in Korea have high infection rates of H. pylori regardless of site specificity, and this infection might be causally associated with stomach cancer.

Keywords: key words, Gastric adenocarcinoma, Helicobacter pylori, CLO test, Cancer causation

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REFERENCES

  • 1. ) Marshall , B. J. and Warren , R. J.Unidentified curved bacilli in the stomach of patients with gastritis and people with ulceration . Lancet , i , 1311 – 1315 ( 1984. ). [DOI] [PubMed] [Google Scholar]
  • 2. ) Lee , A , Fox , J. and Hazell , S.Pathogenicity of Helicobacter pylori: a perspective . Infect. Immun. , 61 , 1601 – 1610 ( 1993. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3. ) Tytgat , G. N. J.Does the stomach adapt to Helicobacter pylori? Scand . J. Gastroenterol. , 193 , 28 – 32 ( 1992. ). [DOI] [PubMed] [Google Scholar]
  • 4. ) Clyne , M. and Drumm , B.Adherence of Helicobacter pylori to primary human gastrointestinal cells . Infect. Immun. , 61 , 4051 – 4057 ( 1993. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5. ) Correa , P. , Haenszel , W. , Cuello , C. , Zavala , D. , Fontham , E. , Zarama , G. , Tannenbaum , S. , Collazos , T. and Ruiz , B.Gastric precancerous process in a high risk population: cohort follow up . Cancer Res. , 50 , 4737 – 4740 ( 1990. ). [PubMed] [Google Scholar]
  • 6. ) Crabtree , J. E. , Wyatt , J. I. , Sobala , G. M. , Miller , G. , Tompkins , D. S. , Primrose , J. N. and Morgan , A. G.Systemic and mucosal humoral responses to Helicobacter pylori in gastric cancer . Gut , 34 , 1339 – 1343 ( 1993. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7. ) Graham , D. Y. , Malaty , H. M. , Evans , D. G. , Evans , D. J. , Klein , P. D. and Adam , E.Epidemiology of Helicobacter pylori in an asymptomatic population in the United States . Gastroenterology , 100 , 1495 – 1501 ( 1991. ). [DOI] [PubMed] [Google Scholar]
  • 8. ) Blaser , M. J. , Chyou , P. H. and Nomura , A.Age at establishment of Helicobactor pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk . Cancer Res. , 55 , 562 – 565 ( 1995. ). [PubMed] [Google Scholar]
  • 9. ) Forman , D. , Sitas , F. , Newell , D. G. , Stacey , A. R. , Boreham , J. , Peto , R. , Campbell , T. C. , Li , J. and Chen , J.Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China . Int. J. Cancer , 46 , 608 – 611 ( 1990. ). [DOI] [PubMed] [Google Scholar]
  • 10. ) Hansson , L. E. , Engstrand , L. , Nyren , O. , Evans , D. J. , Lingren , A. , Bergstrom , R. , Anderson , B. , Athlin , L. , Bendtsen , O. and Tracz , O.Helicobacter pylori infection: independent risk indicator of gastric adenocarcinoma . Gastroenterology , 105 , 1098 – 1103 ( 1993. ). [DOI] [PubMed] [Google Scholar]
  • 11. ) Ahn , Y. O.Diet and stomach cancer in Korea . Int. J. Cancer , 10 , 7 – 9 ( 1997. ). [DOI] [PubMed] [Google Scholar]
  • 12. ) Cohen , A. J. and Roe , F. J.Evaluation of the aetiological role of dietary salt exposure in gastric and other cancers in humans . Food Chem. Toxicol. , 35 , 271 – 293 ( 1997. ). [DOI] [PubMed] [Google Scholar]
  • 13. ) Kang , H. C. and Chung , I. S.Helicobacter pylori and gastric adenocarcinoma in Korea; prevalence and distribution of H. pylori in resected specimen of gastric cancer . J. Cathol. Med. Coll. , 45 , 849 – 863 ( 1992. ). [Google Scholar]
  • 14. ) Boring , C. C. , Squires , T. S. and Tong , T.“Cancer Statistics” ( 1993. ). American Cancer Society, Inc. , Atlanta , GA . [DOI] [PubMed] [Google Scholar]
  • 15. ) Alemohammad , M. M. , Foley , T. J. and Cohen , H.Detection of immunoglobulin G antibodies to Helicobacter pylori in urine by an enzyme immunoassay method . J. Clin. Microbiol. , 31 , 2173 – 2177 ( 1993. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16. ) Andersen , L. P. and Espersen , F.Immunoglobulin G antibodies to Helicobacter pylori in patients with dyspeptic symptoms investigated by the Western immunoblot technique . J. Clin. Microbiol. , 30 , 1743 – 1751 ( 1992. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17. ) Misiewicz , J. J.Helicobacter pylori: past, present, and future . Scand. J. Gastroenterol. , 194 , 25 – 29 ( 1992. ). [DOI] [PubMed] [Google Scholar]
  • 18. ) Westblom , T. U. , Phadnis , S. , Yang , P. and Czinn , S. J.Diagnosis of Helicobacter pylori infection by means of a polymerase chain reaction assay for gastric juice aspirates . Clin. Infect. Dis. , 16 , 367 – 371 ( 1993. ). [DOI] [PubMed] [Google Scholar]
  • 19. ) Bornschein , W. , Bauernfeind , A. and Heilmann , K. L.A rapid urease test in Campylobacter pylori colonization of the gastric mucosa . Gastroenterol. J. , 49 , 54 – 58 ( 1989. ). [PubMed] [Google Scholar]
  • 20. ) Culter , A. F. , Havstad , S. , Ma , C. K. , Blaser , M. J. , Perez‐Perez , C. I. and Schubert , T. T.Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection . Gastroenterology , 109 , 136 – 141 ( 1995. ). [DOI] [PubMed] [Google Scholar]
  • 21. ) Breslow , N. E. and Day , N. E.Statistical methods in cancer research . In“The Analysis of Case‐control Studies,” Vol. 1 , pp. 122 – 159 ( 1980. ). International Agency for Research on Cancer; , Lyon . [PubMed] [Google Scholar]
  • 22. ) Monson , R. R.“Occupational Epidemiology,” 2nd Ed. , pp. 63 – 85 ( 1990. ). CRC Pess; , Boca Raton . [Google Scholar]
  • 23. ) Correa , P. , Fox , J. , Fontham , E. , Ruiz , B. , Lin , Y. , Zavala , D. , Taylor , N. , Mackinley , D. , Lima , E. D. , Portilla , H. and Zarama , G.Helicobacter pylori and gastric carcinoma: serum antibody prevalence in populations with contrasting cancer risks . Cancer , 66 , 2569 – 2574 ( 1990. ). [DOI] [PubMed] [Google Scholar]
  • 24. ) Kim , H. Y. , Cho , B. D. , Chang , W. K. , Kim , D. J. , Kim , Y. B. , Park , C. K. , Shin , H. S. and Yoo , J. Y.Helicobacter pylori infection and the risk of gastric cancer among the Korean population . J. Gastroenterol. Hepatol. , 12 , 100 – 103 ( 1997. ). [DOI] [PubMed] [Google Scholar]
  • 25. ) Loffeld , R. J. L. F. , Willems , I. , Flendrig , J. A. and Arends , J. W.Helicobacter pylori and gastric carcinoma . Histopathology , 17 , 537 – 541 ( 1990. ). [DOI] [PubMed] [Google Scholar]
  • 26. ) Parsonnet , J. , Vandersteen , D. , Goates , J. , Sibley , R. K. , Pritikin , J. and Chang , Y.Helicobacter pylori infection in intestinal‐ and diffuse‐type gastric adenocarcinomas . J. Natl. Cancer Inst. , 83 , 640 – 643 ( 1991. ). [DOI] [PubMed] [Google Scholar]
  • 27. ) Menegatti , M. , Vaira , D. , Miglioli , M. , Holton , J. , Vegura , M. R. , Biasco , G. , Petronelli , A. , Ricci , C. , Azzarone , P. and Gusmaroli , R.Helicobacter pylori in patients with gastric and nongastric cancer . Am. J. Gastroenterol. , 90 , 1278 – 1281 ( 1995. ). [PubMed] [Google Scholar]
  • 28. ) Replogle , M. L. , Glaser , S. L. , Hiatt , R. A. and Parsonnet , J.Biologic sex as a risk factor for Helicobacter pylori infection in healthy young adults . Am. J. Epidemiol. , 142 , 856 – 863 ( 1995. ). [DOI] [PubMed] [Google Scholar]
  • 29. ) Ro , J. Y. , Park , C. I. , Kim , C. J. and Lee , Y. B.A study of gastric carcinoma among Koreans with special reference to the pathogenetic relation of intestinal metaplasia . Yonsei Med. J. , 19 , 35 – 47 ( 1978. ). [DOI] [PubMed] [Google Scholar]
  • 30. ) Lee , J. K. , Park , B. J. , Yoo , K. Y. and Ahn , Y. O.Dietary factors and stomach cancer: a case‐control study in Korea . Int. J. Epidemiol. , 24 , 33 – 41 ( 1995. ). [DOI] [PubMed] [Google Scholar]
  • 31. ) Kim , S. W.A literature review on the epidemiologic characteristics of the H. pylori infection . Thesis for MPH degree , School of Public Health , Seoul National University; ( 1996. ). [Google Scholar]

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