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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1998 Jul;89(7):691–695. doi: 10.1111/j.1349-7006.1998.tb03272.x

Lung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA

Masaaki Inoue 1,2, Toshihiro Osaki 2, Masayuki Noguchi 3,†, Setsuo Hirohashi 3, Kosei Yasumoto 2, Hiroshi Kasai 1,✉
PMCID: PMC5921888  PMID: 9738974

Abstract

The 8‐hydroxydeoxyguanosine (8‐OH‐dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non‐cancer patient controls (n=15). An increased level of 8‐OH‐dG was observed in the lung cancer group, in both the adenocarcinoma and non‐adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non‐cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non‐adenocarcinoma).

Keywords: key words, 8‐Hydroxydeoxyguanosine, Oxidative DNA damage, Lung cancer

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