Table 4. Demographic and clinical characteristics of patients (n = 144) with CIN and ICC treated at the Instituto Nacional de Cancerología-México from 2004 to 2017.
| Variable | CIN (n = 49) | ICC (n = 49) | P-value | ||
|---|---|---|---|---|---|
| n | (%) | n | (%) | ||
| Protein expression | |||||
| Negativea NOTCH1 and negativea NUMB | 10 | (20.41%) | 15 | (15.79%) | 0.014 |
| Negativea NOTCH1 and positiveb NUMB | 0 | (0.00%) | 11 | (11.58%) | |
| Positiveb NOTCH1 and positiveb NUMB | 17 | (34.69%) | 44 | 46.32% | |
| Positiveb NOTCH1 and negativea NUMB | 22 | (44.90%) | 25 | (26.32%) | |
| Protein localization | |||||
| Nuclearc NOTCH1 and nuclearc NUMB | 37 | (75.51%) | 16 | (16.84%) | 0.001 |
| Nuclearc NOTCH1 and cytoplasmicd NUMB | 1 | (2.04%) | 0 | (0.00%) | |
| Cytoplasmicd NOTCH1 and nuclearc NUMB | 11 | (22.44%) | 45 | (47.36%) | |
| Cytoplasmicd NOTCH1 and cytoplasmicd NUMB | 0 | (0.00%) | 34 | (35.78%) | |
CIN: Cervical intraepithelial neoplasia. ICC: Invasive cervical cancer. aThe negative condition was defined as an absence of immunostaining in the sample. bThe positive condition was defined as the presence of any immunostaining in the sample. cNuclear expression was defined as any positive nuclear immunostaining. dCytoplasmic expression was defined as any positive immunostaining outside of the cell nucleus. Bold: statistically significant.