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Effect of Tph treatment (10 mg/kg/day for one month) on BBB tightness in 5XFAD mice. The figure shows representative brain sections stained with anti-IgG antibody to detect IgG extravasation (green) and collagen antibody (red) to detect microvessels, and their optical density quantitation in cortex (a) and hippocampus (b) regions. Data are presented as mean ± SEM of five mice in each group. ***P<0.001 compared to control group. Scale bar, 50 μm.
