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Effect of Tph treatment (10 mg/kg/day for one month) on total Aβ brain levels in 5XFAD mice. Representative brain sections stained with 6E10 antibody against Aβ to detect total Aβ load (green) and collagen antibody (red) to detect microvessels, and their optical density quantitation in cortex (a) and hippocampus (b) regions demonstrate significant reduction in Aβ load. Data are presented as mean ± SEM of five mice in each group. ***P<0.001 compared to control group. Scale bar, 50 μm.
