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. 2018 Mar 21;10(4):419–431. doi: 10.2217/epi-2017-0129

Figure 1. . Pregnancy affects histone methylation levels in nondiabetic women.

Figure 1. 

Dimethylation levels on five histones, expressed as a percentage of total histone H3 levels, were measured in peripheral blood mononuclear cells of never-pregnant women, women at 30 weeks pregnancy, women at 8–10 weeks postpartum and women at 20 weeks postpartum. (A) Dimethylation levels of H3K4 in never-pregnant women compared with women at 30 weeks pregnancy; and dimethylation levels in never-pregnant women compared with women at 20 weeks postpartum. (B) Dimethylation levels of H3K4 women at 30 weeks pregnancy, women at 8–10 weeks postpartum and women at 20 weeks postpartum. (C) Dimethylation levels of H3K9 in never-pregnant women compared with women at 30 weeks pregnancy; dimethylation levels in never-pregnant women compared with 20 weeks postpartum women. (D) Dimethylation levels of H3K9 women at 30 weeks pregnancy, women at 8–10 weeks postpartum and women at 20 weeks postpartum. (E) Dimethylation levels of H3K27 in never-pregnant women compared with women at 30 weeks pregnancy; dimethylation levels in never-pregnant women compared with 20 weeks postpartum women. (F) Dimethylation levels of H3K27 women at 30 weeks pregnancy, women at 8–10 weeks postpartum and women at 20 weeks postpartum. (G) Dimethylation levels of H3K36 in never-pregnant women compared with women at 30 weeks pregnancy; dimethylation levels in never-pregnant women compared with 20 weeks postpartum women. (H) Dimethylation levels of H3K36 women at 30 weeks pregnancy, women at 8–10 weeks postpartum and women at 20 weeks postpartum. (I) Dimethylation levels of H3K79 in never-pregnant women compared with women at 30 weeks pregnancy; dimethylation levels in never-pregnant women compared with 20 weeks postpartum women. (J) Dimethylation levels of H3K79 women at 30 weeks pregnancy, women at 8–10 weeks postpartum and women at 20 weeks postpartum. Values are expressed as a mean percentage of arbitrary units ± standard deviation normalized against total H3 levels.

*p < 0.05; **p < 0.01; ***p < 0.001.