Abstract
Thyroid carcinoma is the first symptom in some patients with familial adenomatous polyposis (FAP). We evaluated the cellular localization of β‐catenin in thyroid carcinomas associated (n=4) or not associated (n=173) with FAP, since loss of functional protein of the adenomatous polyposis coli (APC) gene leads to nuclear accumulation of β‐catenin in adenomas and carcinomas of the FAP colon. Immunoreactive β‐catenin was demonstrated at the cell membrane of glandular cells of the non‐neoplastic thyroid and non‐FAP carcinomas. On the other hand, cytoplasmic and nuclear accumulation of β‐catenin is specific to FAP‐associated papillary carcinomas. The abnormality in the APC/β‐catenin pathway is thus also important in FAP‐associated thyroid carcinoma, and β‐catenin immunohistochemistry is a feasible screening method to identify occult FAP in young patients with thyroid tumors.
Keywords: Familial adenomatous polyposis, β‐Catenin, Thyroid carcinoma, Papillary carcinoma, Immunohistochemistry
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REFERENCES
- 1. ) Iwama , T. , Mishima , Y. and Utsunomiya , J.The impact of familial adenomatous polyposis on the tumorigenesis and mortality at the several organs . Ann. Surg. , 217 , 101 – 108 ( 1993. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2. ) Plail , R. O. , Bussey , H. J. , Glazer , G. and Thomson , J. P.Adenomatous polyposis: an association with carcinoma of the thyroid . Br. J. Surg. , 74 , 377 – 380 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 3. ) Su , L.‐K. , Vogelstein , B. and Kinzler , K. W.Association of the APC tumor suppressor protein with catenins . Science , 262 , 1734 – 1737 ( 1993. ). [DOI] [PubMed] [Google Scholar]
- 4. ) Henderson , B. R.Nuclear‐cytoplasmic shuttling of APC regulates β‐catenin subcellular localization and turnover . Nat. Cell Biol. , 2 , 653 – 660 ( 2000. ). [DOI] [PubMed] [Google Scholar]
- 5. ) Inomata , M. , Ochiai , A. , Akimoto , S. , Kitano , S. and Hirohashi , S.Alteration of β‐catenin expression in colonic epithelial cells of familial adenomatous polyposis patients . Cancer Res. , 56 , 2213 – 2217 ( 1996. ). [PubMed] [Google Scholar]
- 6. ) Kashiwagi , H. , Konishi , F. , Kanazawa , K. and Miyaki , M.Sisters with familial adenomatous polyposis affected with thyroid carcinoma, desmoid tumour and duodenal polyposis . Br. J. Surg. , 83 , 228 ( 1996. ). [DOI] [PubMed] [Google Scholar]
- 7. ) Iwama , T. , Konishi , M. , Iijima , T. , Yoshinaga , K. , Tominaga , T. , Koike , M. and Miyaki , M.Somatic mutation of the APC gene in thyroid carcinoma associated with familial adenomatous polyposis . Jpn. J. Cancer Res. , 90 , 372 – 376 ( 1999. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8. ) Garcia‐Rostan , G. , Tallini , G. , Herrero , A. , D'Aquila , T. G. , Carcangiu , M. L. and Rimm , D. L.Frequent mutation and nuclear localization of β‐catenin in anaplastic thyroid carcinoma . Cancer Res. , 59 , 1811 – 1815 ( 1999. ). [PubMed] [Google Scholar]
- 9. ) Carrato , A. , Fulciniti , F. , Avallone , A. , Benincasa , G. , Palombini , L. and Grieco , M.Beta‐ and gamma‐catenin expression in thyroid carcinomas . J. Pathol. , 185 , 267 – 272 ( 1998. ). [DOI] [PubMed] [Google Scholar]
- 10. ) Chong , J. , Kurihara , K. , Koshiishi , N. , Fukazawa , T. , Kubono , S. , Kawai , T. and Fukayama , M.Aspiration and imprint cytopathology of the thyroid carcinoma associated with familial adenomatous polyposis . Diagn. Cytopathol. , 23 , 101 – 105 ( 2000. ). [DOI] [PubMed] [Google Scholar]