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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 2001 Apr;92(4):377–382. doi: 10.1111/j.1349-7006.2001.tb01105.x

Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones

Naruhiko Takasawa 1,2, Naoto Ishii 1, Norikazu Higashimura 1, Kazuko Murata 1,6, Yuetsu Tanaka 4, Masataka Nakamura 5, Takeshi Sasaki 3, Kazuo Sugamura 1,6,✉
PMCID: PMC5926725  PMID: 11346458

Abstract

gp34, which we previously cloned, is a ligand of OX40 (CD 134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 expression is observed on activated T cells, while OX40L is expressed in antigen‐presenting cells. However, cytotoxic T lymphocyte (CTL) clones specific for Epstein‐Barr virus (EBV)‐transformed autologous lymphoblastic cell lines (LCLs) induced both OX40 and OX40L expression after antigen or T cell receptor (TCR) stimulation. This study suggests a possible function of OX40L/OX40, through T cell‐T cell interaction, in the reactivation of memory T cells in an auto‐crine manner, with implications for the pathogenesis of viral infections and neoplasms.

Keywords: gp34, OX40 ligand (OX40L), OX40, T cell clones

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