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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 2002 Jan;93(1):85–92. doi: 10.1111/j.1349-7006.2002.tb01204.x

Anti‐tumor Effect of Chemically Synthesized Sulfolipids Based on Sea Urchin's Natural Sulfonoquinovosylmonoacylglycerols

Hiroeki Sahara 1, Shinya Hanashima 2, Takayuki Yamazaki 2, Shunya Takahashi 3, Fumio Sugawara 2, Seiji Ohtani 4, Masako Ishikawa 4, Yoshiyuki Mizushina 2, Keisuke Ohta 2, Kumiko Shimozawa 1, Shinsei Gasa 5, Kouichi Jimbow 1, Kengo Sakaguchi 2, Noriyuki Sato 4, Nobuaki Takahashi 1,✉
PMCID: PMC5926865  PMID: 11802812

Abstract

We recently reported that 3′‐sulfonoquinovosyl‐1′‐monoacylglycerol (designatedA‐5) extracted from sea urchin intestine was effective in suppressing the growth of solid tumors. Although the major fatty acid component of A‐5 was a saturated C16 acid, there were five other fatty acids, 14:0, 18:0, 14:1, 16:1, and 18:1, which constitute minor components of A‐5. Therefore, it remains unclear as to which of these six fatty acid components of A‐5 has the anti‐tumor effect. In this study, we synthesized sulfolipids each containing only one of these six fatty acids and tested their cytotoxicity against tumor cells and in vivo anti‐tumor effects on nude‐mice bearing solid tumors of human lung adenocarcinoma cell line A‐549. The IC50 values of all products against tumor cells were more than 10‐5M, suggesting weak cytotoxic activity compared with other chemotherapeutic compounds for cancer. On the other hand, in vivo anti‐tumor assay showed that sulfoquinovosyl‐monoacylglycerols (SQMG) composed of 14:1 and 18:1 (designated SQMG(14:1) and SQMG(18:1), respectively) were significantly effective in suppressing the growth of solid tumors. Our data suggested that these two SQMGs had a substantial anti‐tumor effect in vivo, and they are of interest as candidate drugs for anti‐cancer treatment.

Keywords: Glycolipid, Sulfoglycolipid, Anti‐tumor effect, Cancer chemotherapy

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