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. 2018 Mar 15;103(5):908–918. doi: 10.3324/haematol.2017.184416

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Figure 7. — Antiphospholipid antibodies modulate the expression of both the circulating miRNAs that integrate the signature in antiphospholipid syndrome (APS) and their putative protein targets. Human umbilical vein endothelial cells (HUVECs) were treated with antiphospholipid antibodies and secreted selected microRNAs (miRNAs) (A) and putative target protein (B) levels were determined in the supernatant. Monocytes were also treated with antiphospholipid antibodies and secreted selected miRNAs (C) and putative target proteins (D) levels were evaluated in the supernatant of culture. Differences were analyzed by Student t-test. Values are the means and Standard Error of Mean of 4 independent experiments performed in triplicate. P<0.05 was considered statistically significant. TF: tissue factor; PAI-1: plasminogen activator inhibitor-1; VEGF-A: vascular endothelial growth factor A; VEGF-R1: VEGF-Receptor-1; MCP-1: monocyte chemotactic protein.