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. 2018 Mar 28;8(9):2496–2507. doi: 10.7150/thno.24677

Figure 1.

Figure 1

Kinds of ncRNAs-derived small peptides involved in theranostics. Some genome genes are transcribed to be ncRNAs including housekeeping ncRNAs (tRNAs, rRNAs and snRNAs) and regulatory ncRNAs. The functions of these ncRNAs are relatively clear. Regulatory ncRNAs include miRNAs, lncRNAs, circRNAs and transcripts from repeat sequences. As illustrated, by binding with ribosomes in the cytoplasm, these ncRNAs are further translated into small peptides. Circ-ZNF609 is translated and the produced small peptides function in myogenesis. These small peptides are involved in regulating muscle performance, suppressing colon cancer growth, promoting embryo cells internalization/migration, leading to FTLD/ALS and accumulation of mature miRNAs. (FTLD/ALS: frontotemporal lobar degeneration and amyotrophic lateral sclerosis; lncRNAs: long non-coding RNAs; miRNAs: microRNAs; ncRNAs: non-coding RNAs;rRNAs: ribosomal RNAs; snRNAs: small nuclear RNAs; tRNAs: transfer RNAs).