Skip to main content
. 2018 Apr 13;9(28):19508–19524. doi: 10.18632/oncotarget.24628

Table 3. Cox regression analysis of prognostic factors for overall survival.

Variables Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value
Gender 0.39
Male 1
Female 1.7 0.5 - 6.0
Age 0.27
< 70 1
≥ 70 1.7 0.7 - 4.6
T category 0.099
Ta 1
T1 2.5 0.8 - 7.8
Tis 4.5 1.1 - 18.1
Tumor Grade 0.05 0.61
Low 1 1
High 3 1.0 - 9.1 0.58 0.07 - 4.8
INF < 0.0001 0.022
No 1 1
Yes 6.6 2.5 - 17.4 7.8 1.3 - 44.9
CIS 0.034 0.45
No 1 1
Yes 2.8 1.1 - 7.5 1.8 0.4 - 8.3
LVI 0.014 0.59
No 1 1
Yes 3.2 1.3 - 7.9 1.7 0.3 - 10.4
KLγ expression 0.013 0.025
Low 1 1
High 3.6 1.2 - 10.9 4.3 1.2 - 15.3

The high expression level of KLγ was not an independent poor prognostic factor.

Abbreviations: KLγ, γ–klotho; INF, infiltration; CIS, carcinoma in situ; LVI, lymphovascular invasion; HR, hazard ratio; CI, confidence interval.