Table 3. Cox regression analysis of prognostic factors for overall survival.
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Gender | 0.39 | ||||||
| Male | 1 | ||||||
| Female | 1.7 | 0.5 - 6.0 | |||||
| Age | 0.27 | ||||||
| < 70 | 1 | ||||||
| ≥ 70 | 1.7 | 0.7 - 4.6 | |||||
| T category | 0.099 | ||||||
| Ta | 1 | ||||||
| T1 | 2.5 | 0.8 - 7.8 | |||||
| Tis | 4.5 | 1.1 - 18.1 | |||||
| Tumor Grade | 0.05 | 0.61 | |||||
| Low | 1 | 1 | |||||
| High | 3 | 1.0 - 9.1 | 0.58 | 0.07 - 4.8 | |||
| INF | < 0.0001 | 0.022 | |||||
| No | 1 | 1 | |||||
| Yes | 6.6 | 2.5 - 17.4 | 7.8 | 1.3 - 44.9 | |||
| CIS | 0.034 | 0.45 | |||||
| No | 1 | 1 | |||||
| Yes | 2.8 | 1.1 - 7.5 | 1.8 | 0.4 - 8.3 | |||
| LVI | 0.014 | 0.59 | |||||
| No | 1 | 1 | |||||
| Yes | 3.2 | 1.3 - 7.9 | 1.7 | 0.3 - 10.4 | |||
| KLγ expression | 0.013 | 0.025 | |||||
| Low | 1 | 1 | |||||
| High | 3.6 | 1.2 - 10.9 | 4.3 | 1.2 - 15.3 | |||
The high expression level of KLγ was not an independent poor prognostic factor.
Abbreviations: KLγ, γ–klotho; INF, infiltration; CIS, carcinoma in situ; LVI, lymphovascular invasion; HR, hazard ratio; CI, confidence interval.