Table 1.

The role of fat-soluble vitamins in multiple sclerosis.

Vitamins	Vitamin serum level in patients	Immune-related role	Neural- or myelin-related role	Clinical remarks	References
Vitamin D	Low	Anti-inflammatory	Improves oxidation in white matter (at high doses)	Risk of hypercalcaemia in the Case of over consumption	[11], [12], [13], [14], [15], [16], [28], [30], [33], [34], [35], [37], [38], [39], [40], [43], [44]
Vitamin A	Low	Anti-inflammatory	Improves astrocytes anti-inflammatory function	Suppresses immune responces improves remyelination	[48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
Vitamin E	Low	No evidence	Inhibits necrosis factors improves oligodenrocytes functions	Reduces annual relapses improve remyelination	[81], [82], [83], [90], [91], [92], [93], [94], [95], [96], [97], [98]
Vitamin K	No evidence	No evidence	Effective in oligodendrocyte survival		[99], [100], [101]