Table 1. RNA and protein expression of RHAMM in normal human tissues.
| RHAMM Expression | |||
|---|---|---|---|
| Normal tissue type | RNA* | Protein | |
| Solid tissues | |||
| adrenal | N.D. | 0 | |
| brain | 0 | 0 (in cerebrum and cerebellum) | |
| breast | N.D. | 0 | |
| cervix | N.D. | 0 | |
| colon | 0 | scattered positive cells in the proliferative zones at base of crypts | |
| esophagus | N.D. | 0 | |
| liver | 0 | 0 | |
| lung | + | 0 | |
| heart | 0 | 0 | |
| kidney | 0 | 0 | |
| ovary | 0 | 0 | |
| pancreas | + | 0 | |
| pituitary | N.D. | 0 | |
| placenta | ++ | a subset of positive trophoblast cells in the full-term placenta | |
| prostate | 0 | 0 | |
| salivary gland | N.D. | 0 | |
| skeletal muscle | 0 | 0 | |
| skin | 0 | scattered positive cells in basal and parabasal layers | |
| small intestine | N.D. | scattered positive cells in the proliferative zones at base of crypts | |
| spleen | 0 | 0 | |
| stomach | N.D. | 0 | |
| thyroid | N.D. | 0 | |
| testis | ++ | most abundant RHAMM expression among all normal adult tissues, see text | |
| uterus | N.D. | 0 | |
| Hematopoietic and lymphoid tissues | |||
| peripheral blood | 0 | N.D. | |
| bone marrow | N.D. | scattered positive cells | |
| lymph node/tonsil | N.D. | most of the positive cells clustered in the dark zones of the germinal centers; occasional positive cells in the paracortical areas | |
| thymus | ++ | positive cells abundant in the thymic cortex but absent in the medulla | |
*0: under detection limit; +: low level RNA expression; ++: high level RNA expression; RNA data summarized from [17]. N.D.: not determined.