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Incidence of adverse events (>10% of all grades), regardless of study drug relationship
| Adverse event | Grade 3/4 n (%) |
All grades n (%) |
|---|---|---|
| Any | 30 (60) | 50 (100) |
| Diarrhea | 12 (24) | 38 (76) |
| Fatigue | 1 (2) | 25 (50) |
| Neuropathy peripheral | 2 (4) | 14 (28) |
| Nausea | 0 | 14 (28) |
| Headache | 1 (2) | 11 (22) |
| Constipation | 0 | 9 (18) |
| Muscular weakness | 0 | 8 (16) |
| Dehydration | 3 (6) | 7 (14) |
| Insomnia | 0 | 7 (14) |
| Vomiting | 0 | 7 (14) |
| Convulsion | 2 (4) | 6 (12) |
| Edema peripheral | 1 (2) | 6 (12) |
| Dyspnea | 0 | 6 (12) |
| Rash | 0 | 6 (12) |
