Fig. 3.

Imaging of a representative case of CMV retinitis showing OCT findings in areas of active retinitis, the leading edge of retinitis, and beyond the leading edge of retinitis noted on fundus photographs. A. Fundus photographs of a case of macular CMV retinitis in the left eye in which the largest focus was over the superior arcades with retinal whitening and hemorrhage. The area of active retinitis (red circle), leading edge of retinitis (blue circle), and area of retina just beyond the leading edge (yellow circle) are noted. B. Fundus autofluorescence imaging of the same patient showed hypo- and hyperautofluorescence in the areas of active retinitis with a hyperautofluorescent border at the leading edge, the boundaries of which are not clearly evident. The area of active retinitis (red circle), leading edge of retinitis (blue circle), and area of retina just beyond the leading edge (yellow circle) are noted. C–E. Optical coherence tomography imaging through the area of active retinitis (C), leading edge of retinitis (D), and beyond the leading edge of retinitis (E) reveal microstructural abnormalities. (C) The area of active retinitis (red arrow) reveals severe retinal architectural disruption and obliteration of the EZ and ELM. D. The leading edge (red arrow) reveals moderate retinal architectural disruption with thickening and irregularity of the EZ (red arrowhead), absence of the ELM (red arrowhead), and subretinal fluid and hyperreflective subretinal deposits (red arrowhead). E. The area beyond the leading edge of retinitis (red arrow) reveals relatively intact retinal architecture but a few intraretinal hyperreflective foci, thickening and irregularity of the EZ, intact ELM, and subretinal fluid and hyperreflective deposits.