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. 2018 May 12;391(10133):1916–1926. doi: 10.1016/S0140-6736(18)30792-X

Table 3.

Effect of the interventions on incidence of clinical episodes of falciparum and vivax malaria

Plasmodium falciparum
Plasmodium vivax
IRR 95%CI p value IRR 95%CI p value
Type of village
No MDA (non-hotspot or unknown) 1 Ref 1 Ref
Hotspot before MDA* 2·69 1·80–4·04 <0·0001 1·87 1·32–2·67 <0·0001
Hotspot after MDA* 0·50 0·31–0·80 <0·0001 0·48 0·32–0·73 <0·0001
Duration of malaria post activity in the village, by type of village (linear approximation, per quarter increment)
No MDA (non-hotspot or unknown) 0·75 0·73–0·78 <0·0001 0·93 0·91–0·94 <0·0001
Hotspot before MDA 0·82 0·76–0·88 <0·0001 0·93 0·87–0·98 <0·0001
Hotspot after MDA 0·99 0·92–1·06 <0·0001 1·05 1·00–1·11 <0·0001
Number of MDA done within the village tract excluding the village (per village increment) 0·96 0·92–1·00 0·0471 0·98 0·95–1·01 0·2538
Coverage of villages within the village tract (+10%) 0·90 0·87–0·93 <0·0001 0·92 0·90–0·95 <0·0001
Malaria post embedded in a community clinic 1·75 1·15–2·66 0·0087 1·44 1·04–2·00 0·0293

Data presented by the regional elimination programme. Incidence rate ratios (IRR) show the relative contribution of mass drug administration (MDA), community-based malaria posts, and coverage to the decrease in village-level and incidence after adjustment for seasonality, geographical location, and other interventions in a multivariable analysis. p values correspond to the inclusion of the three-category variable.

*

Using the category hotspot before MDA as the reference, this translates to IRR 0·19 (0·13–0·26) for the hotspot after MDA.