Table 1.
Characteristics of colorectal cancer patients who received adjuvant chemotherapy by prevalence of chemotherapy-induced peripheral chemotherapy (CIPN).
| CIPN | |||
|---|---|---|---|
| Total Population n = 196 | CIPN No n = 36 (18%) | Yes 1 n = 160 (82%) | |
| Gender, women | 71 (36%) | 12 (33%) | 59 (37%) |
| Age (years) | 64.0 (59.8–68.1) | 65.4 (59.0–68.2) | 63.7 (59.9–68.0) |
| Diabetes mellitus (yes) 2 | 15 (8%) | 3 (8%) | 12 (8%) |
| Physical activity (meeting norm) 3 | 143 (73%) | 25 (69%) | 118 (74%) |
| Tumor stage | |||
| Stage II | 15 (8%) | 2 (6%) | 13 (8%) |
| Stage III | 145 (74%) | 28 (76%) | 117 (73%) |
| Stage IV | 21 (10%) | 3 (9%) | 18 (11%) |
| Missing | 15 (8%) | 3 (9%) | 12 (8%) |
| Cancer site | |||
| Colon | 181 (93%) | 33 (92%) | 148 (93%) |
| Rectum | 14 (7%) | 3 (8%) | 11 (7%) |
| Missing | 1 (0%) | 0 (0%) | 1 (0%) |
| Type of chemotherapy | |||
| Oxaliplatin-containing (OX) | 166 (85%) | 27 (75%) | 139 (87%) |
| Capecitabine monotherapy | 23 (12%) | 9 (25%) | 14 (9%) |
| Other | 2 (1%) | 0 (0%) | 2 (1%) |
| Missing | 5 (2%) | 0 (0%) | 5 (3%) |
| Dietary factors | |||
| Magnesium intake from diet (mg/day) 2,4 | 317 (261–383) | 325 (261–396) | 313 (261–380) |
| Use of magnesium supplements (yes) | 36 (18%) | 6 (17%) | 30 (18%) |
| Calcium intake from diet (mg/day) 2,4 | 851 (621–1143) | 789 (597–1155) | 861 (631–1123) |
| Use of calcium supplements (yes) | 35 (18%) | 6 (17%) | 29 (18%) |
| Vitamin D intake from diet (mg/day) 2,4 | 3.1 (2.4–4.1) | 2.8 (2.2–3.7) | 3.2 (2.4–4.2) |
| Total energy intake (kcal/day) 2,4 | 1893 (1534–2265) | 1898 (1547–2230) | 1893 (1534–2285) |
| CIPN 5 | |||
| Total score 6 | 14.6 (6.3–26.4) | 0.0 (0–2.1) | 16.7 (10.4–29.2) |
| Sensory score 7 | 16.7 (4.2–37.5) | 0.0 (0–0) | 20.8 (12.5–37.5) |
| Motor score 8 | 8.3 (4.2–20.8) | 0.0 (0–0) | 12.5 (8.3–20.8) |
Values presented are median (quartile 1–quartile 3) or number (percentage). 1 Cut-off point for CIPN total score: 3.6, 2 Assessed at diagnosis. 3 Meeting the Dutch physical activity guideline of 150 min per week of moderate intensive exercise at baseline, 4 Intake is missing for two patients, 5 Assessed 12 months after diagnosis. 6 Data for one patient missing. 7 Data for two patients missing. 8 Data for five patients missing.