Table 2.
Multivariate analysis of patients receiving hematopoietic cell transplantation for follicular lymphoma from 2001-2011.
| Outcome/Factors | N | RR (95% CI) | P-value |
|---|---|---|---|
|
| |||
| Progression/Relapse | |||
|
| |||
| Histologic Grade | |||
| Grade 1 | 444 | 1.00 | |
| Grade 2 | 383 | 1.32 (0.95 – 1.84) | 0.101 |
| Grade 3 | 308 | 1.63 (1.16 – 2.28) | 0.004 |
| Missing | 388 | 1.20 (0.85 – 1.68) | 0.294 |
|
| |||
| Disease status at HCT | |||
| Chemosensitive | 1.158 | 1.00 | |
| Chemorefractory | 253 | 1.46 (1.07 – 1.97) | 0.015 |
| Missing | 112 | 1.23 (0.79 – 1.93) | 0.362 |
|
| |||
| Transplant Related Mortality | |||
|
| |||
| Age (Continuous) | 1.523 | 1.04 (1.02 – 1.05) | < 0.0001 |
|
| |||
| N. of prior chemotherapy lines | |||
| 1-2 | 285 | 1.00 | 0.008 |
| 3-4 | 390 | 1.56 (1.12 – 2.17) | |
| >=5 | 165 | 2.53 (1.77 – 3.62) | <0.0001 |
| Missing | 683 | 1.84 (1.35 – 2.51) | 0.0001 |
|
| |||
| KPS | |||
| >= 80 | 986 | 1.00 | |
| < 80 | 54 | 2.05 (1.32 – 3.19) | 0.001 |
| Missing | 483 | 0.94 (0.76 – 1.16) | 0.556 |
|
| |||
| Conditioning regimen | |||
| RIC/NMA | 1.168 | 1.00 | - |
| MAC | 355 | 1.49 (1.18 – 1.87) | 0.0007 |
|
| |||
| Disease status at HSCT | |||
| Chemosensitive | 1.158 | 1.00 | |
| Chemoresistant | 253 | 1.61 (1.28 – 2.03) | <0.0001 |
| Missing | 112 | 1.14 (0.78 – 1.66) | 0.510 |
|
| |||
| Progression free survival | |||
|
| |||
| Histology | |||
| Grade 1 | 444 | 1.00 | |
| Grade 2 | 383 | 1.15 (0.94 – 1.42) | 0.177 |
| Grade 3 | 308 | 1.42 (1.15 – 1.76) | 0.001 |
| Missing | 388 | 1.17 (0.94 – 1.44) | 0.154 |
|
| |||
| N. of prior chemotherapy lines | |||
| 1-2 | 285 | 1.00 | |
| 3-4 | 390 | 1.33 (1.04 – 1.70) | 0.022 |
| >=5 | 165 | 1.93 (1.46 – 2.55) | < 0.0001 |
| Missing | 683 | 1.56 (1.24 – 1.95) | 0.0001 |
|
| |||
| KPS | |||
| >= 80 | 986 | 1.00 | |
| < 80 | 54 | 1.78 (1.23 – 2.58) | 0.002 |
| Missing | 483 | 0.96 (0.81 – 1.14) | 0.634 |
|
| |||
| Disease status at HSCT | |||
| Chemosensitive | 1.158 | 1.00 | |
| Chemoresistant | 253 | 1.54 (1.28 – 1.86) | <0.0001 |
| Missing | 112 | 1.15 (0.86 – 1.54) | 0.336 |
|
| |||
| Conditioning regimen | |||
| RIC/NMA | 1.168 | 1.00 | |
| MAC | 355 | 1.36 (1.14 – 1.63) | 0.0008 |
|
| |||
| Overall Survival | |||
|
| |||
| Age (Continuous) | 1.523 | 1.03 (1.02 – 1.04) | > 0.0001 |
|
| |||
| Histology | |||
| Grade 1 | 444 | 1.00 | |
| Grade 2 | 383 | 1.17 (0.93 – 1.48) | 0.180 |
| Grade 3 | 308 | 1.44 (1.13 – 1.83) | 0.003 |
| Missing | 388 | 1.29 (1.01 – 1.63) | 0.039 |
|
| |||
| N. of prior chemotherapy lines | |||
| 1-2 | 285 | 1.00 | |
| 3-4 | 390 | 1.48 (1.11 – 1.97) | 0.007 |
| >=5 | 165 | 2.41 (1.77 – 3.30) | < 0.0001 |
| Missing | 683 | 1.73 (1.33 – 2.26) | < 0.0001 |
|
| |||
| KPS | |||
| >= 80 | 986 | 1.00 | |
| < 80 | 54 | 2.23 (1.52 – 3.25) | < 0.0001 |
| Missing | 483 | 0.89 (0.73 – 1.07) | 0.219 |
|
| |||
| Disease status at HCT | |||
| Chemosensitive | 1.158 | 1.00 | <0.0001 |
| Chemoresistant | 253 | 1.59 (1.30 – 1.95) | 0.227 |
| Missing | 112 | 1.20 (0.86 – 1.67) | |
|
| |||
| Conditioning regimen | |||
| RIC/NMA | 1.168 | 1.00 | |
| MAC | 355 | 1.42 (1.16 – 1.73) | 0.0006 |
RR = Relative risk; CI = Confidence interval; HCT = Stem cell transplantation; KPS. Karnofsky performance score; ASCT = Autologous stem cell transplantation; RIC = Reduced intensity conditioning; NMA = Non-myeloablative conditioning regimen; MAC = Myeloablative conditioning regimen.