Figure 8.

Cognitive flexibility is impaired in CGG animals. Numbers of ETC (A, C, E, and G) and TTC (B, D, F, and H) were recorded. A, B, In Phase 1, CGG animals were significantly impaired, in comparison to WT mice, in sessions SD learning, CD Learning, and Conflict Learning. C, D, CGG animals and WT animals performed similarly in Phase 2 sessions CD Learning 2 and Conflict Learning 2. E, F, In Phase 3, CGG and WT animals performed comparably in session CD Learning 3 but CGG animals displayed continued cognitive impairment in session Conflict Learning 3. G, H, In Phase 4, no significant differences were observed in the performances of CGG and WT animals in session CD Learning 4 and Conflict Learning 4. EDS, extradimensional shift; IDS, intradimensional shift. n = 9 for each animal group (CGG and WT).