Skip to main content
. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Anesthesiology. 2018 Jun;128(6):1220–1236. doi: 10.1097/ALN.0000000000002191

Figure 7. Resiniferatoxin reduces the spontaneous activity of dorsal horn neurons and precludes CPP to dermorphin [D-Arg2, Lys4] (1–4) amide (DALDA) in nerve-injured rats.

Figure 7

(A) The spontaneous activity rates of WDR neurons in vehicle-pretreated SNL rats were significantly decreased by DALDA (10 mg/kg, s.c.). The baseline spontaneous activity rates were significantly lower in SNL rats that received resiniferatoxin pretreatment (0.1 mg/kg, i.p, n=7) than in those that received vehicle (n=6). Two-way mixed-model ANOVA with Bonferroni post hoc test, *P < 0.05, **P < 0.01 versus baseline; #P < 0.05 versus the indicated group. (B) SNL rats pretreated with vehicle (n=7), but not resiniferatoxin (0.1 mg/kg, i.p, n=11), spent more time in the DALDA-paired chamber (10 mg/kg, s.c.) after conditioning, than they did during the preconditioning test period. (C) The difference scores. Two-way repeated measures ANOVA with Bonferroni post hoc test, **P < 0.01 versus the indicated group or the saline-paired chamber. Data are expressed as mean ± SD. ANOVA, analysis of variance; APs, action potentials; CPP, conditioned place preference; i.p., intraperitoneal; RTX, resiniferatoxin; s.c., subcutaneous; WDR, wide-dynamic range.