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. 2017 Nov 21;19(5):1435–1444. doi: 10.1021/acs.biomac.7b01403

Scheme 1. Synthetic Pathway to Block Copolymer-Modified SPION.

Scheme 1

MeTos: methyl tosylate, IPOx: 2-isopropyloxazoline, EtOx: 2-ethyloxazoline. (a–c) End group transformation: (a) quench with water, (b) reaction with succinic anhydride, (c) reaction with 6-nitrodopamine, ligand exchange reaction of NDA-modified block copolymers on oleic acid-coated SPION.