Table 6.
Survival | Number of patients | Percent | Event-free survival | Overall survival | ||||
---|---|---|---|---|---|---|---|---|
Variable | 5 year (%) | SE (%) | P (log-rank) | 5 year (%) | SE (%) | P (log-rank) | ||
Total | 23 | |||||||
Age | ||||||||
<32 years (median) | 12 | 52 | 64 | 15 | 0.438 | 61 | 15 | 0.828 |
>32 years | 11 | 48 | 39 | 21 | 67 | 20 | ||
Sex | ||||||||
Male | 13 | 57 | 44 | 18 | 0.791 | 39 | 17.5 | 0.235 |
Female | 10 | 43 | 63 | 18 | 89 | 10.5 | ||
Tumor site | ||||||||
Tarsus | 16 | 70 | 49 | 16 | 0.903 | 57 | 15 | 0.503 |
Other | 7 | 30 | 71 | 17 | 80 | 18 | ||
Tumor size | ||||||||
<31.5 cm3 (median) | 5 | 50 | 80 | 18 | 0.786 | 80 | 18 | 0.366 |
>31.5 cm3 | 5 | 50 | 67 | 27 | 67 | 27 | ||
Primary metastases | ||||||||
No | 20 | 87 | 66 | 13 | 0.005 | 78 | 11 | 0.008 |
Yes | 3 | 13 | 0 | 0 | 0 | 0 | ||
AP | ||||||||
Normal | 15 | 75 | 60 | 16 | 0.216 | 57 | 16 | 0.568 |
Elevated | 5 | 25 | 30 | 24 | 53 | 25 | ||
LDH | ||||||||
Normal | 16 | 84 | 68 | 14 | 0.076 | 62 | 15 | 0.291 |
Elevated | 3 | 16 | 0 | 0 | 33 | 27 | ||
Duration of symptoms | ||||||||
<154 days (median) | 11 | 55 | 76 | 16 | 0.188 | 76 | 16 | 0.463 |
>154 days | 9 | 45 | 29 | 22 | 51 | 20 | ||
Delay of chemotherapy | ||||||||
<21 days | 8 | 35 | 58 | 19 | 0.532 | 73 | 17 | 0.441 |
>21 days | 15 | 65 | 52 | 17 | 57 | 17 | ||
Timing of operation | ||||||||
After preoperative chemotherapy | 18 | 78 | 52 | 14 | 0.929 | 64 | 13 | 0.587 |
Primary surgery | 5 | 22 | 67 | 27 | 67 | 27 | ||
Type of surgery | ||||||||
Resection | 4 | 17 | 75 | 22 | 0.660 | 75 | 22 | 0.347 |
Amputation | 19 | 83 | 45 | 15 | 60 | 14 | ||
Surgical remission | ||||||||
Complete remission | 21 | 95 | 60 | 13 | 0.000 | 72 | 12 | 0.000 |
Macroscopic residual | 2 | 9 | 0 | 0 | 0 | 0 | ||
Tumor response | ||||||||
Good | 4 | 24 | 38 | 29 | 0.980 | 67 | 27 | 0.435 |
Poor | 13 | 76 | 64 | 15 | 59 | 16 |
5-year event-free and overall survival and P values in the log-rank test for all variables (see Data collection and Definition of Variables). SE = standard error; P = two-sided P values.