Skip to main content
. 2018 Apr 24;9(31):22158–22183. doi: 10.18632/oncotarget.25243

Figure 9. Proteogenomic database analysis of patient breast tumors.

Figure 9

(A) Heat map of copy number alteration (CNA), mRNA expression, and protein expression of Abl (ABL1), Arg (ABL2) and cortactin (CTTN) across 102 tumor samples based on the CPTAC database. ER, estrogen receptor positive; PR, progesterone receptor positive; HER2, HER2 positive, TN, triple negative. GISTIC, mRNA and protein abundance z-scores are shown for each sample. (B) mRNA expression analysis of 1,905 samples originated from TCGA with different hormone receptor statuses. (C) Comparison of protein abundance in 102 samples from different hormone receptor statuses. The boxes in B and C is delimited by the lower and upper quartile, the horizontal red line indicates the sample median and whiskers extend to the most extreme point which is no more than 1.5 times the interquartile range from the box. Outliers are shown as points beyond boxplot whiskers. P values were calculated using two-tailed Student’s t-test. (D). GISTIC analysis of 1,905 samples originated from TCGA with different hormone receptor statuses. (E–G) Pearson correlation between ABL1-CTTN, ABL2-CTTN and ABL1-ABL2 protein abundances. ***P ≤ 0.001 as determined by Student’s t test.