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. 2018 Apr 24;9(31):21674–21686. doi: 10.18632/oncotarget.24670

Figure 2. In vivo efficacy of selumetinib + DTIC.

Figure 2

(A-C) Tumor growth inhibition obtained with selumetinib with and without DTIC in the three UM PDXs, MP34 (A), MP55 (B), and MM26 (C). Tumor growth was evaluated by plotting mean RTV (relative tumor volume) ± SEM for each group. (D-F) Overall responses to selumetinib (D), DTIC (E), and selumetinib + DTIC (F). (G) Probability of progression after selumetinib treatment with or without DTIC, taking tumor doubling time into account. (H) In vivo relapses after DTIC-induced complete remission, for the MM26 UM PDX, with and without selumetinib administration.