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. 2018 May 1;9(33):23058–23077. doi: 10.18632/oncotarget.25208

Figure 8. IFN-γ with trastuzumab and pertuzumab induce senescence and apoptosis in breast cancer cells.

Figure 8

(A) SK-BR-3 and HCC-1419 cells, untreated, or treated with 10 ug/ml of trastuzumab and pertuzumab (TP), and incubated with increasing concentrations IFN-γ for SK-BR-3 and HCC-1419. Left panel, densitometric analysis presented as % of SA-β-gal-positive cells, mean ± SD (n = 3), *p < 0.05, **p < 0.01, ***p < 0.001; ns, not significant. Right panel: representative data from 1 of 3 independent experiments in SK-BR-3 cells (top panel) and HCC-1419 cells (bottom panel). (B and C) p15INKb and cleaved caspase-3 expression of SK-BR-3 (B) and HCC-1419 (C) cells described in A. Vinculin was used as loading control. Similar results were observed in 3 independent experiments.