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The Scientific World Journal logoLink to The Scientific World Journal
. 2004 Jan 16;4:1–8. doi: 10.1100/tsw.2004.1

Adenosine Receptors and Wound Healing

Bruce N Cronstein 1
PMCID: PMC5956376  PMID: 14755098

Abstract

Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy of diabetic foot ulcers. The effects of adenosine A2A receptors on the cells and tissues of healing wounds have only recently been explored. We review here the known effects of adenosine A2A receptor occupancy on the cells involved in wound healing.

Keywords: Adenosine, adenosine receptor, angiogenesis, inflammation, granulation tissue


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