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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Neuroscience. 2018 Apr 18;380:103–110. doi: 10.1016/j.neuroscience.2018.04.009

Figure 2.

Figure 2

Odor habituation was impaired in ApoE4 mice compared to ApoE2 mice, with ApoE3 mice performing intermediately. (A) Habituation in 6-month-old mice, normalized to investigation on the first trial (ApoE2 n = 9, ApoE3 n = 6, ApoE4 n = 6). (B) Habituation in 12-month-old mice, normalized to investigation on the first trial (ApoE n = 6, ApoE3 n = 9, ApoE4 n = 4). (C) Direct comparison of age and genotype effects on odor habituation (average over trials 2-4). Histograms are means ± s.e.m. All individual data for each group are also plotted. Older mice showed less habituation than younger mice (left panel, p = 0.04). ApoE4 mice showed less habituation compared to ApoE2 (right panel, p = 0.02) while ApoE3 mice performed nominally, but not significantly, in-between ApoE2 and ApoE4 (right panel).