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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Ophthalmology. 2018 Feb 1;125(6):815–821. doi: 10.1016/j.ophtha.2017.12.014

Figure 2. Receiver operating characteristic curves predicting primary open angle glaucoma for weighted GRS.

Figure 2

The curves are based on logistic regression models adjusting for age and gender without and with the weighted GRS constructed from previously reported VCDR SNPs, the weighted GRS generated from lead SNPs, and the weighted GRS derived from our genome-wide association data. AUC represents the area under the curve, with a larger AUC representing better classification of POAG status. The addition of weighted GRS derived from our own genome-wide association data significantly improved the discriminatory ability for POAG (P < 0.0001).