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. 2018 Apr 13;145(8):dev163824. doi: 10.1242/dev.163824

Fig. 5.

Fig. 5.

Reoriented Wnt5a expression gradient changes digit morphogenesis. (A) Illustration of altering Wnt5a expression gradient from distal-proximal axis to posterior-anterior axis. (B) Wnt5a whole-mount in situ hybridization in mouse E11.5 forelimb buds. (C) Sox9 whole-mount in situ hybridization in mouse E12.5 forelimb buds. Each digit is numbered and the third digit is outlined. The angles between digit 3 and digit 4 were measured using their longitudinal axes. The arrows point to the posteriorly tilted digit 3. A, anterior; P, posterior. Digits 1-5 are labeled. Scale bars: 200 μm.