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a–f In vivo hemodynamic studies. Septic shock was defined as MAP decreased by 25–30% of its baseline value. Septic shock in rats was induced by intravenous injection of LPS (E. coli 055:B5, 15 mg/kg, 0.1 mL/min) and rats injected (i.v.) with saline were used as controls. LV function was monitored over the entire 6 h of LPS/saline injection. ** p < 0.01, * p < 0.05 versus saline; ## p < 0.01 versus the respective baseline. n = 6.
