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. 2018 May 28;5(3):ENEURO.0130-18.2018. doi: 10.1523/ENEURO.0130-18.2018

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Copyright © 2018 Vann et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 10. — Effects of brief photostimulation on V_T and Φ_N+1 in Dbx1;CatCh mice (n = 4, cyan) or wild-type littermates (n = 4, magenta). A₁, Phase-response curve plotting Φ_N+1 versus Φ_Stim throughout the breathing cycle in sedated mice. A₂, Phase-response curve for changes in V_T following photostimulation (i.e., the perturbed breath) in the same cohort of sedated mice (n = 4). The abscissa marks the inspiratory (I, 0–150°) and expiratory (E, 150–360°) phases of the breathing cycle (0–360°), which applies to A₁, A₂. B₁, Phase-response curve plotting Φ_N+1 versus Φ_Stim in awake unrestrained mice. B₂, Phase-response curve for ΔV_T versus Φ_Stim in the same cohort of awake unrestrained mice. The abscissa marks the inspiratory (I, 0–110°) and expiratory (E, 110–360°) phases of the complete breathing cycle (0–360°), which applies to B₁, B₂.