Fig. 2.
IL-10 in PSA-experienced T cells is dispensable for protection against tissue inflammation. WT mice receiving 2 × 106 PSA-experienced IL-10n cells as described in Figure 1 were used to harvest lung tissue. Fixed and inflated lungs were sectioned and stained with H&E or EpCAM (green) and myeloperoxidase (red) antibodies. Animals receiving intranasal (i.n.) OVA challenges and saline exposed IL-10n T cells showed myeloperoxidase-positive leukocyte infiltration in and around the major airways, airway epithelial expression of myeloperoxidase and epithelial hyperplasia. PSA-experienced IL-10n T cells, in contrast, prevented these pathologies and returned tissue histology to that seen with saline (PBS) challenged mice. This figure is available in black and white in print and in color at Glycobiology online.