Fig. 4.

PSA-mediated Inhibition of tissue inflammation requires recipient-derived IL-10. IL-10n mice receiving 2 × 10⁶ PSA-experienced WT cells as described in Figure 3 were used to harvest lung tissue. Fixed and inflated lungs were sectioned and stained with H&E or EpCAM (green) and myeloperoxidase (red) antibodies. Animals receiving intranasal (i.n.) OVA challenges and saline exposed WT T cells showed myeloperoxidase-positive leukocyte infiltration in and around the major airways, airway epithelial expression of myeloperoxidase and epithelial hyperplasia. Likewise, PSA-experienced WT T cells failed to prevent these pathologies and did not return tissue histology to that seen with saline (PBS) challenged mice. This figure is available in black and white in print and in color at Glycobiology online.