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Regional differences in biomarker trajectories. Top: The difference in the longitudinal rates of change of PIB measurements (A) and cortical thickness (B) between APOE ɛ4 carriers and non-carriers in two cortical regions. Bottom: The difference in the longitudinal rates of change of PIB (C) and volume (D) between APOE ɛ4 carriers and non-carriers in two subcortical regions.
